Pyrimidinylpyrazole derivatives and methods for preparing the same

ABSTRACT

WHEREIN R3 and R5 are each hydrogen or alkyl of one to five carbon atoms, Py is a pyrimidinyl group optionally substituted by alkyl of one to five carbon atoms, alkoxy of one to five carbon atoms, and/or halogen, Z is N-(optionally substituted)phenyl piperazino, 4-substituted piperidino or 4-substituted-1,2,5,6tetrahydro pyridino. The compounds are useful either as C.N.S. depressants or as antihypertensive agents.   Pyrimidinylpyrazole derivatives, having the formula:

United States Patent 1 Ueno et al.

[54] PYRIMIDINYLPYRAZOLE DERIVATIVES AND METHODS FOR PREPARING THE SAME [75] Inventors: Katsuhiro Ueno; Yoshiaki Ohmura; Reimei Moroi; Akira Akashi; Masahiro Arimoto; Akira Kasahara, all of Tokyo, Japan [73] Assignee: Daiichi Seiyaku Co., Ltd., Tokyo,

Japan [22] Filed: July 31, 1970 [21] Appl. No.: 60,112

[30] Foreign Application Priority Data Aug. 2, 1969 Japan ..44/6l2l8 Aug. 15, 1969 Japan .Q ..44/64542 [52] US. Cl ..260/256.4 C, 260/2564 N, 260/168 PH, 260/268 C, 260/999 [51] Int. Cl. ..C07d 51/42 [58] Field of Search ..260/256.4 N, 256.4 C

[56] References Cited OTHER PUBLICATIONS Adams et al., Organic Reactions, Vol. I (1942) John Wiley Press, pp. 334-337 [4 1 Mar. 27, 1973 Primary Examiner-Donald G. Daus Assistant Examiner-R. V. Rush Attorney0blon, Fisher & Spivak [57] ABSTRACT Pyrimidinylpyrazole derivatives, having the formula:

32 Claims, No Drawings PYRIMIDINYLPYRAZOLE DERIVATIVES AND METHODS FOR PREPARING THE SAME The present invention relates to novel pyrimidinylpyrazole derivatives and to a process for preparing the 5 same, and more particularly to a compound having the following general formula (I):

wherein R and R each represent a hydrogen atom or an alkyl group having one to five carbon atoms, Py represents a pyrimidinyl group which may have one or more substituents selected from the group consisting of an alkyl group having one to five carbon atoms,an alkoxy group having one to five carbon atoms, and a halogen atom;and wherein Z represents:

in which 0 represents a phenyl group which may have the formula II:

- wherein R R and Py each have the same meaning as above. The amine useful in this invention has the structure Z-H, wherein Z has the same meaning as above.

The starting material (II) is also a novel compound and can be synthesized by the following procedure: hydrazinopyrimidine derivatives of the formula Py-NHNI-I are heated with a compound of the formula:

(Ill) In no CIIMCOCII;

( 01M (IV) 1) Unit wherein Py, R and R have the same meaning as designated above. The reaction is conducted at a temperature of between room temperature and C. in a suitable solvent, such as water, methanol, ethanol, dioxane or mixture thereof, to yield the compound designated by II.

The Mannich reaction may then proceed by heating a mixture of the raw materials at 50C. C. in an inert solvent, such as ethanol or dioxane. Either an amine having the structure Z-H or a salt thereof such as monohydrochloride or monohydrobromide can be used in the reaction with good results. The term functional derivative of formaldehyde refers to a substance which is capable of providing formaldehyde in the reaction, such as paraformaldehyde. The product I can be isolated as a free base or a salt from the reaction mixture by conventional techniques.

The compounds represented by the formula I are highly active for depressing the central nervous system (CNS. depressant) or for reducing the blood pressure- (antihypertensive), and accordingly are considered to be useful medicaments. I

It is known that compounds having the following structure (VI) are useful as C.N.S. depressants and antihypertensive agents:

wherein A in formula VI includes approximately the same radicals as those in the formula I. The compounds of formula VI, however, differ from those of formula I in that the prior art compounds VI possess a phenyl group attached to the N of the pyrozole ring,whereas the compound I possesses a pyrimidinyl group. Unlike the compounds of VI, the compounds of formula 1 possess either a significant C.N.S. depressant activity or a significant antihypertensive activity,whereas the compounds of the formula VI will possess a significant degree of both characteristics. For example, referring to Table 1, it will be seen that the compounds designated as No. 1,330 and No. 1,530 show a high C.N.S. depressant activity and very low antihypertensive activity,and the compounds designated as No. 1440 and No.1430 show a very low C.N.S. depressant activity and high antihypertensive activity.

In contradistinction, l-phenyl-4-(3-(4-o-tolyl-1- piperazinyl) l-oxopropyl S-methyl-pyrazole hydrochloride (No. 1,000 in Table l) which is representative of the compounds VI of the prior art is characterized by both high C.N.S. depressant activity and high antihypertensive activity.

The coexistence of both C.N.S. depressant and antihypertensive activities limits the extent of clinical ap- TABLE 1 Compound No. l No.1330 No.1530 No.1000

C.N.S. depressant activity (ED 50 mg/kg)No. 2

Antihypertensive activity No. 3

TABLE I1 Compound No.l No.1440 No.1430 No.1340 No.1000

C.N.S.depressant activity (ED 50 mg/kg)No. 2 86.1

Antihypertensive activity No. 3 H-l- No. 1 No. 1000: l-phenyl-4-( 3-(4-o-tolyll piperazinyl)-1-oxopropyl)-5 -methylpyrazole hydrochloride No.13 30: 1-( 2-pyrimidinyl )-4-( 3-(4-p-fluorophenyll -piperazinyl l -oxopropyl )-5 -methylpyrazole hydrochloride No.15 30: 1-( 2-pyrimidinyl)-4-( 3-(4-o-fluorophenyll -piperazinyl l -oxopropyl )-5 -methylpyrazole hydrochloride N01440: 1-(4,6-dimethyl-2-pyrimidinyl)-4-( 3-(4- o-chlorophenyl-1-piperazinyl)-1-oxopropyl)-5- methylpyrazole hydrochloride hydrate N01430: 1-(4-methoxy-6-methyl-2-pyrimidinyl 4-(3-(4-o-chloro-phenyl-l-piperazinyl)-1-oxopropyl)-5-methylpyrazole hydrochloride hydrate N01 340: 1-(4-methoxy-6-methyl-2-pryimidinyl)-4- (3-( 4-o-tolyll -piperazinyl l -oxopropyl )-5- methylpyrazole hydrochloride No. 2 The C.N.S. activity was determined by the rotarod test. Mice were placed on a wooden rod, 3 cm in diameter, and rotated at 14 r.p.m. Sideward movements on the rod was limited by two circular discs set 8.5 cm apart. Mice were given 2 minutes training on the rod. Only those mice which could stay on the rod for at least 60 consecutive seconds were used in this test. These mice were orally administered the test compounds dissolved in water, and were given two test trials at 30 minutes, l,2,3,and 4 hours,respectively, Each trial lasted a maximum of 60 seconds. Mice unable to stay on the rod for 60 consecutive seconds during both test trials were scored as being affected. ED values were calculated according to the method of Litchfield and Wilcoxon from rates of response at the time when the maximum effect was observed. No. 3 Renal hypertensive rats were prepared by the infraction method. The animals with stable systolic blood pressure levels,above 160 mml-lg, were used for this test. Test compounds were dissolved in water and administered to the animals orally. The blood pressure was measured by tail plethysmography at 30 minutes, 1,2,4,6,and 24 hours following administration. The degree of the corresponding fall in blood pressure was expressed by the symbolsz-H-i- (intensive), -H- (moderate), or +(slight).

Having generally described the invention,a more complete understanding can be obtained by reference to certain specific examples which are provided herein for purposes of illustration only and are not intended to be limiting in any manner.

PREPARATION OF STARTING MATERIAL (II) EXAMPLE 1 To a solution of ethoxymethylene acetylacetone (3.30 g) dissolved in ethanol (40 g),2-

hydrazinopyrimidine (4.68 g) was added at 10 to 15C. and warmed at 50 to 60C. for 1 hour. The reaction solution was allowed to stand overnight to form a crystalline precipitate. This precipitate was collected by filtration. Secondary crystals were obtained by concentration of the filtrate and recrystallization from ethanol. The total yield of 1-(2-pyrimidinyl)-4-acety1- 5-methylpyrazole was 5.5 g which had a melting point of 130 to 131C.

EXAMPLE 2 A mixture of ethoxymethylene acetylacetone 3.1 g), 4-methoxy-2-hydrazinopyrimidine (2.8 g), and ethanol ml) was refluxed for 4 hours. The reaction solution was concentrated. The resulting crystals were collected by filtration and recrystallized from ethanol to give 4.2 grams of l-(4-methoxy-2-pyrimidinyl)-4- acetyl-S-methyl pyrazole having a melting point of 117- 118C.

Elementary analysis for C H N O Calcd C5689 H5.2l N24.l3 Found C 56.66 H 4.94 N 23.80

EXAMPLE 3 To a A suspension of 4,6-dimethyl-2- hydrazinopyrimidine (13.82 g) in methanol ethoxymethylene acetylacetone (17.18 g) was added dropwise with stirring at about 30C. The reaction solution was then refluxed for 1 hour and concentrated in vacuo. The resulting crystals were collected by filtration and recrystallized from methanol to provide 21.68 grams of l-(4,6-dimethyl-2-pyrimidinyl)-4-acetyl-5- methylpyrazole having a melting point of 100 to 103C.

Elementary analysis for C I-I N O Calcd C 62.59 H 6.13 N 24.33

Found C 62.63 H 5.99 N 24.35

EXAMPLE 4 To a mixture of ethoxymethylene acetylacetone (3.12 g) and ethanol (20 ml), a solution of 4-methoxy- 6-methyl-2-hydrazinopyrimidine (3.08 g) dissolved in ethanol was added dropwise at 5 15C. and heated to 50C. for 1 hour. The residue, which was obtained from the reaction solution by means of concentration in vacuo, was recrystallized from ether to yield l-(4- methoxy--methyl-2-pyrimidinyl)-4-acetyl-5-methylpyrazole (4.6 g) having a melting point of 126C.

Elementary analysis for C, 144O Calcd C 58.52 H 5.72 N 22.75 Found C 58.27 H 5.57 N 22.95

EXAMPLE 5 A mixture of ethoxymethylene acetylacetone (3.94 g), 4-methoxy-5-bromo-6-methyl-2- hydrazinopyrimidine (5.61 g), and ethanol (100 ml) was refluxed for 2.5 hours. The reaction solution was concentrated in vacuo and the residue was dissolved in benzene. The benzene solution was subjected to chromatography in an alumina column. The column was eluted with benzene and then with a mixture of benzene and chloroform 95 5). The eluates were concentrated and the residue was recyrstallized from methanol to yield 1-(4-methoxy-5-bromo-6-methyl-2- pyrimidinyl)-4-acetyl-5-methylpyrazole (1.58 g) having a melting point of 160 163C.

Elementary analysis for C H N O Br Calcd C 44.32 H 4.03 N 17.23 Br 24.57 Found C 44.41 H 3.93 N 17.43 Br 25.03

EXAMPLE 6 To a solution of 4,6-dimethyl-2-hydrazinopyrimidine (8.51 g) and methanol (80 ml), ethoxymethylene acetylacetone (8.59 g) was added with stirring at about 30C. and refluxed for 1 hour. The reaction solution was cooled and the resulting crystals were collected by filtration. The crystals were recrystallized from methanol to yield l-(4,6-dimethoxy-2-pyrimidinyl)-4- acetyl-S-methylpyrazole (10.21 g) having a melting point of 124- 126C.

Elementary analysis for C H N O Calcd C 54.95 H 5.38 N 21.37

Found C 55.22 H 5.25 N 21.20

EXAMPLE 7 A mixture of ethoxymethylene-acetylacetone (7.8 g), 4-hydrazinopyrimidine (5.5 g) and ethanol (130 ml) was refluxed for 30 minutes. The crystals obtained from the reaction solution by concentration in vacuo were collected by filtration and recrystallized from methanol to yield 1-(4-pyrimidinyl)-4-acetyl-5-methylpyrazole (8.2 g) having a melting point of 134- 135C.

Elementary analysis for C l-l N O Calcd C 59.39 H 4.98 N 27.71

Found C 59.24 H 4.97 N 27.55

EXAMPLE 8 A mixture of ethoxymethylene-acetylacetone (3.1 g), 6-methoxy-4-hydrazinopyrimidine (2.8 g) and ethanol (100 ml) was refluxed for 5 hours. The crystals obtained from the reaction solution by concentration in vacuo were collected by filtration and recrystallized from ethanol to yield 1-(6-methoxy-4-pyrimidinyl)-4- acetyl-S-methylpyrazole (4.0 g) having a melting point of 131 132C.

Elementary analysis for C H N O Calcd C 56.89 H 5.21 N 24.13

Found C 56.72 H 4.97 N 24.48

PREPARATION OF PRODUCT COMPOUND 1:

EXAMPLE 9 1-( 2-pyrimidinyl)-4-acetyl-5-methylpyrazole 10.1 g). Nphenyl-piperazine monohydrochloride (9.9 g)

and paraformaldehyde (9.0 g) were refluxed with ethanol (400 ml) for 40 hours. The reaction solution was concentrated in vacuo, and the residue was dissolved in water and extracted with ethyl acetate to remove the excess pyrazole. The water layer was alkalized with sodium bicarbonate and extracted with ethyl acetate. The extracted solution was washed with water,dried, and the solvent was removed. The residue was recyrstallized from methanol to yield 1-(2- pyrimidinyl)-5-methyl-4-[3-(4-phenylpiperazino)-1- oxopropyl]-pyrzaole having a melting point of 146 148C.

Elementary analysis for C H N O Calcd C 67.00 H 6.43 N 22.33

Found C 67.03 H 6.29 N 21.93 The crystals,with a melting point of 146 148C., were treated with hydrochloric acid and recrystallized from methanol to obtain the hydrochloric acid salt having a melting point of 194- 197C.

Elementary analysis for C H N O. HCl

Calcd C 61.08 H 6.10 N 20.36 Cl 8.59 Found C 60.48 H 6.34 N 20.34 Cl 8.12

EXAMPLE 10 A mixture of 1-(2-pyrimidinyl)-4-acetyl-5-methylpyrazole (1.01 g), N-o-tolyl-piperazine monohydrochloride (1.07 g) paraformaldehyde (0.90 g) and ethanol (50 ml) were refluxed for 50 hours. The reaction solution was concentrated and the resulting crystals were collected by filtration,recrystallized from methanol to obtain 1-(2-pyrimidinyl)-5-methyl-4-[3- (4-o-tolylpiperazino l -oxopropyl]-pyrazo1e, hydrochloride having a melting point of 197 202C. (decomp.).

Elementary analysis for C H N OHCI Calcd C 61.89 H 6.38 N 19.69 Cl 8.31 Found C6l.76 H6.81 N 19.91 Cl8.69

EXAMPLE 11 A mixture of 1-(2-pyrimidinyl)-4-acetyl-5-methylpyrazole (5.06 g),N-p-tolylpiperazine,monohydrochloride (5.31 g),paraformaldehyde (4.5 g) and ethanol ml) was refluxed for 62 hours. The reaction solution was concentrated and the remaining syrup was dissolved in water. The excess pyrazole was removed by extraction with benzene. After the aqueous layer was allowed to stand,the resulting crystals were collected by filtration and recrystallized from a solution of methanol and ethanol to give 1- (2-pyrimidinyl )-5 -methyl-4-[ 3-( 4-p-tolylpiperazino 1- oxopropyll-pyrazole hydrochloride having a melting point of 195 196C. (decomp.).

Elementary analysis for c H N QHClCl-l Ol-l Calcd C 60.19 H 6.81 N 18.31 C17.72

Found C 60.23 H 6.41 N 18.76 Cl 8.12

The above hydrochloride salt was neutralized with potassium carbonate and the resulting crystals were recrystallized from ether to yield a free base having a melting point of 108 109C.

Elementary analysis for C l-1 151 0 Calcd C 67.67 H 6.71 N 21.52

Found C 67.87 H 7.14 N 22.08

EXAMPLE 12 EXAMPLE 13 A mixture of l-(2-pyrimidinyl)-4-acetyl-5-methylpyrazole (202g), N-m-chlorophenylpiperazine.minohydrochloride (2.33 g), paraformaldehyde (1.8 g) and ethanol (25 ml) was treated in the same manner as in Example 12 to obtain 1-(2-pyrimidinyl )--methyl-4-[ 3-(4-m-chlorophenylpiperazino l oxopropyl]-pyrazole hydrochloride having a melting point of 185 188C. (decomp.). (Yield: 50.3 percent) Elementary analysis for C H N OCLHCI:

Calcd C 56.38 H 5.41 N 18.79 Cl15.85

Found C 56.60 H5.18 N 18.63 Cl15.75

EXAMPLE 14 A mixture of 1-(2-pyrimidinyl)-4-acetyl-5-methylpyrazole 1 .01 g) ,N-p-chlorophenylpiperazine,monohydrochloride (1.17 g), paraformaldehyde (0.90 g) and ethanol (50 ml) was refluxed for 60 hours. After cooling,the resulting crystals were recrystallized from ethanol to obtain l-(2-pyrimidinyl)5-methyl-4 3-( 4-p-chlorophenylpiperazino- 1 -oxopropyl] pyrazole.hydrochloride having a melting point of215- 218C. (decomp.).

Elementary analysis for C H N OCLHCI:

Calcd C 56.38 H 5.41 N 18.79 Cl 15.85 Found C 56.41 -H 5.56 N 18.40 Cl 15.75

EXAMPLE 15 A mixture of l-(Z-pyrimidinyl)-4-acetyl-5-methylpyrazole (2.02 g), N-p-fluorophenylpiperazinehydrochloride (2.17 g), paraformaldehyde (1.80 g), and ethanol (25 ml) was refluxed for 40 hours. After cooling,the resulting crystals were recrystallized from water to obtain l-(2-pyrimidinyl)- 5 -methyl-4- 3-( 4-p-fluorophenylpiperazino l -oxopropyl]-pyrazole.hydrochloride having a melting point of 197- 203C. (decomp.

Elementary analysis for C H N OEHCI Calcd C58.53 H5.6l N 19.51 Found C 58.03 H 5.76 N 19.24

EXAMPLE 16 A mixture of l-( 2pyrimidinyl)-4-acetyl-5-methylpyrazole 2.02 g ,N-o-methoxyphenylpiperazine.monohydrobromide (2.72 g), paraformaldehyde (1.80 g),and ethanol 100 ml) was refluxed for 40 hours. The reaction solution was treated in the same manner as in Example 12 to yield l-(2-pyrimidinyl)-5- methyl-4-[ 3-(4-o-methoxyphenylpiperazino l -0xopropyl]-pyrazole.hydrobromide having a melting point of 199 200C. (decomp.).

Elementary analysis for C H N O .HBr.1.5H O

Calcd C 51.66 H 5.91 N 16.43 Br 15.63 Found C 51.38 H 5.80 N 16.62 Br 15.40

EXAMPLE 17 A mixture of l-(4-pyrimidinyl)-4-acetyl-5-methylpyrazole (5.05 g), N-phenylpiperazinemonohydrochloride (5.65 g),paraformaldehyde (4.5 g),and ethanol (250 ml) was refluxed for 40 hours. After cooling,the resulting crystals were collected by filtration and washed with benzene. The crystals were recrystallized from water to yield 1-(4- pryimidinyl)-5-methyl-4-[3-(4-phenylpiperazino)-1- oxopropyl-]-pyrazole.hydrochloride having a melting point of 209 210C.(decomp.).

Elementary analysis for C H N OHCI. l/4H O:

Calcd C 60.42 H 6.16 N 20.12 Cl 8.49 Found C 60.48 H 6.28 N 19.91 C1839 EXAMPLE 18 A mixture of 1-(4-pyrimidinyl)-4-acetyl-5-methylpyrazole 1.01 g),N-o-tolylpiperazinemonohydrochloride ((1.06 g),paraforma1- dehyde (0.90 g) and ethanol (50 ml) was refluxed for 40 hours. After cooling,the resulting crystals were collected by filtration and washed with ethyl acetate. The crystals were recrystallized from water to yield 1-(4- pyrimidinyl)5-methyl-4-S-[ 3-(4-o-tolylpiperazino l oxopropyl]-pyrazole.hydrochloride having a melting point of 234- 236C. (decomp.).

Elementary analysis for C H N OJ-1Cl Calcd C61.89 H638 N 19.69 CL 18.31

Found C 61.67 H 6.26 N 19.64 Cl 8.12

EXAMPLE 19 A mixture of 1-(4-pyrimidinyl)-4-acetyl-5-methylpyrazole (1.01 g), N-p-chlorophenyl-piperazine. monohydrochloride (1.17 g), paraformaldehyde (0.90 g) and ethanol (50 ml) was refluxed for 30 hours. After cooling,the resulting crystals were collected by filtration and washed with ethyl acetate. The crystals were recrystallized from water to yield 1-(4-pyrimidinyl)-5- methyl-4-[ 3-( 4-p-chlorophenylpiperazino 1 -oxopropyl]-pyrazole.hydrochloride having a melting point of218 219C. (decomp.).

Elementary analysis for C H N OCLHCl Calcd C 56.38 H 5.41 N 18.79

Found C 56.54 H 5.53 N 18.77

EXAMPLE 20 A mixture of l-(4-methoxy-2-pyrimidinyl)-4-ace'tyl- S-methylpyrazole l 1.6 g) N-phenylpiperazine.monohydrochloride (11.3 g), paraformaldehyde (9.0 g),and ethanol (500 ml) was refluxed for 40 hours. The reaction solution was concentrated in vacuo. A syrup obtained was dissolved in water and washed with benzene. The aqueous layer was concentrated. The resulting crystals from water to yield l-(4- methoxy-2-pyrimidinyl)-5-methyl-4-[3-(4-phenylpiperazino)-1-oxopropyl]-pyrazole.hydrochloride having a melting point of 193- 194C. (decomp.).

Elementary analysis for C H N O HCl Calcd C 59.65 H 6.14 N 18.97 Cl 8.00 Found C 59.68 H 5.96 N 18.40 Cl 7.93

EXAMPLE 21 A mixture of 1-(6-methoxy-4-pyrimidinyl)-4-acetyl- S-methylpyrazole l 1.6 g),N-phenylpiperazine.monohydrochloride (11.3 g), paraformaldehyde (9.0 g),and ethanol (500 ml) was refluxed for 40 hours. The reaction solution was treated in the same manner as in Example 20 to yield l-( 6-methoxy-4- pyrimidinyl )--methyl-4-[ 3-( 4-phenyl-piperazino l oxopropyl]-pyrazole hydrochloride having a melting point of 199 200C. (decomp.).

Elementary analysis for c n N o na Calcd C 59.65 H 6.14 N 18.97 C1800 Found C 59.63 H 6.14 N 19.25 Cl 7.96

Example 22 EXAMPLE 23 A mixture of 1-(Z-pyrimidinyl)-4-acety1-3,5- dimethylpyrazole (432 mg), N-o-tolylpiperazine.monohydrochloride (425 mg),paraformaldehyde (360 mg), and ethanol ml) was refluxed for 40 hours. The reaction solution was concentrated. The

resulting crystals were collected by filtration and recrystallized from ethanol to yield 1-( 2-pyrimidinyl)- 3 ,5-dimethyl-4- 3 4-o-tolylpiperazino 1 -oxopropyl] pyrazole.hydroch1oride having a melting point of 184 188.5C. 1

EXAMPLE 24 A mixture of l-(2-pyrimidinyl)-4-acetyl-5-rnethylpyrazole (6.06 g),4-phenylpiperidine hydrochloride (5.90 g),paraformaldehyde (5.4 g) and ethanol (100 ml) was refluxed for 41 hours. A syrup obtained from the reaction solution by concentration was dissolved in water and the excessive starting materials were removed by extraction with benzene. The aqueous layer was treated with potassium carbonate to form a basic solution and extracted with benzene. The benzene solution was subjected to chromatography in a silica gel (30 g) column. The column was eluted with a mixture of chloroform and ethyl acetate (9 1) and with a mixture of chloroform and methanol (100 l). The eluates were treated with methanolic hydrogen chloride. The resulting crystals were recrystallized from water to yield 1-(2-pryimidinyl)-4-[3-(4-pheny1- "l -piperidyl l -oxopropyl ]-5-methylpyrazole.hydrochloride having a melting point of 176 178.5C.

Elementary analysis for C H N 011C]. 1 [2 H O Calcd C 62.77 H 6.47 N 16.64 C 18.42 Found C 62.90 H 6.28 N 16.81 C18.53

EXAMPLE 25 A mixture of l-(2-pyrimidinyl)-4-acetyl-5-methylpyrazole (3.03 g) .4-(4-chlorophenyl)-piperidine-4-0l hydrochloride (3.72 g), paraformaldehyde (2.70 g) 0 and ethanol ml) was refluxed for 42 hours. The

resulting crystals were recrystallized from methanol to yield 1-(2-pyrimidinyl)-4-[3-(4-p-chlorophenyl-4- hydroxyl -piperidyl 1 -oxopropyl l-5-methylpyrazole.hydroxhloride' having a melting point of 218 Elementary analysis for C H N,O Cl.1-1Cl Calcd C 57.15 H 5.45 N 15.15 Cl15.38 Found C 57.21 H 5.24 N 15.41 Cl15.69

EXAMPLE 26 A mixture of l-(Z-pyrimidinyl)-4-acetyl-5-methylpyrazole (5.05 g),4-phenyl-1,2,5 ,6-

tetrahydropropyridine.hydrochloride (4.89 g), paraformaldehyde (4.50 g) and ethanol (100 ml) was refluxed for 42 hours. A syrup obtained from the reaction solution by'concentration was dissolved in water and extracted with benzene. The resulting crystals from the aqueous layer were collected by filtration and recrystallized from water to yield 1-( 2-pyrimidinyl)-4- [3-(4-phenyl-1 ,2,5 ,6-tetrahydrol -pyridyl l-oxopropyl]-5-methylpyrazole.hydrochloride with a melting point of l- 173C.

Elementary analysis for C H N O.HCl

Calcd C64.46 H5.90 N 17.08 Cl8.65 Found C64.20 116.60 N 16.78 Cl8.48

EXAMPLE 27 A mixture of 1-(2-pryimidinyl)-4-acetyl-5-methylpyrazole (3.30 g) 4-(4-fluorophenyl)-1,2,5,6-

tetrahydropyridine hydrochloride (3.50 g),paraformaldehyde (3.6 g) and ethanol (50 ml) was refluxed for 45 hours. The resulting crystals were collected by filtration and recrystallized from water and then from methanol to yield l-(2-pyrimidinyl) 4-[3-(4-pfluorophenyl- 1 ,2,5 ,6-tetrahydro-1-pyridyl)-1-oxopropyl]-5-methylpyrazole.hydrochloride having a melting point of 198 202C.

Elementary analysis for C l-1 N 01= .l-lCl. 1 [211 0:

Calcd C 60.47 H 5.54 N 16.03 Found C 60.27 H 5.75 N 16.19

EXAMPLE 28 A mixture of l-(2-pyrimidinyl)-4-acetyl-5-methylpyrazole 1.62 g),4-(4-chlorophenyl)-1,2,5 ,6-

tetrahydropyridine.hydrochloride (1.84 g),paraforma1- dehyde (1.44 g) and ethanol (40 ml) was refluxed for 45 hours. The resulting crystals were collected by filtration and recrystallized from water to yield 1-(2- pyrimidinyl)-4-[3-(4-p-chlorophenyl)-1 ,2,5 ,6- tetrahydro- 1 -pyridyl l -oxopropyl]-5-methylpyrazole.hydrochloride with a melting point-of 202 204C.

Elementary analysis for C H N OCLHCL1/2H O:

Calcd C 58.25 H 5.34 N 15.45 Cl15.64

Found C 58.17 114.97 N 15.58 Cl15.77

EXAMPLE 29 A mixture of 1-(4,6-dimethyl-2-pyrimidinyl)-4- acetyl-S-methylpyrazole (5.00 g),4-phenyl-1,2,5,6- tetrahydropyridine.hydrochloride (4.26 g),paraformaldehyde (5.0 g) and methanol (60 ml) was refluxed for 38 hours. The reaction solution was concentrated in vacuo and warmed with benzene. The resulting crystals were collected by filtration and recrystallized from methanol to yield 1-(4,6-dimethyl-2-pyrimidinyl)-4-[3- (4-phenyl )-1 ,2,5 ,6-tetrahydro-1-pyridyl)-l-oxopropyl]--methylpyrazole.hydrochloride with a melting point of 170 173C.

Elementary analysis for C H N OHCL 1/2H O Calcd C 64.49 H 6.54 N 15.67 Cl 7.93

Found C 64.50 H 6.53 N 16.04 Cl 7.75

EXAMPLE 30 A mixture of 1-(4-methoxy-6-methyl-2-pryimidinyl)- 4-acetyl-5-methyl-pyrazole (2.46 g),N-o-tolylpiperazine.monohydrochloride (2.13 g),paraformaldehyde (1.80 g) and ethanol (50 ml) was refluxed for 40 hours. After cooling, crystals precipitated were collected and recrystallized from water to yield l-(4- methoxy-6-methyl-2-pyrimidinyl )-5-methyl4-( 3-( 4- tolylpiperazino)-l'oxopropyl pyrazole hydrochloride having a melting point of 209 21 1C. (decomp.).

Elementary analysis for C H N 0,.HC1

Calcd C 61.20 H 6.63 N 17.89 Cl 7.53

Found C 61.30 H 6.59 N 17.59 C17.43

Having now described the invention,it will be apparent to one of ordinary skill in the art that many changes and modificationscan be made without departing from the spirit or scope of the invention.

What is claimed as new and desired to be secured by letters patent is:

l. A compound represented by the formula:

COCHzCHzZ in which Q is a phenyl group or a substituted phenyl group having one or more substituents selected from the group consisting of an alkyl group having one to five carbon atoms, an alltoxy group having one to five carbon atoms, a halogen atom and a trifluoromethyl group, and R is a hydrogen atom or an hydroxy group.

2. The compound of claim 1 which is:

l-( Z-pyrimidinyl )-5-methyl-4-( 3-( 4-phenylpiperazino 1 -oxopropyl pyrazole.

3. The compound of claim 1 which is:

1-( 2-pyrimidinyl )-5-methyl-4-[ 3-( 4-o-tolylpiperazino)-1-oxopropyl1-pyrazole.

4. The compound of claim 1 which is:

1-(2-pyrimidiny1)-5-methyl-4-[3-(4-p-to1y1- piperazino 1 -oxopropyl ]-pyrazo1e.

5. The compound of claim 1 which is:

l-( Z-pyrimidinyl)-5-methyl-4-[3-( 4-o-chlorophenylpiperazino)-l-oxopropyl]-pyrazole.

6. The compound of claim 1 which is:

l-(2-pyrimidinyl)-5-methyl-4-[3-(4-m-chlorophenylpiperazino)-l-oxopropyl1-pyrazole.

7. The compound of claim 1 which is:

l-(2-pyrimidinyl)-5-methyl-4-[3-(4-p-chlorophenlpiperazino 1 -oxopropyl -pyrazole.

8. The compound of claim 1 which is: I-(Z-pyrimidinyl)-5-methyl-4-[ 3-(4-p-fluoropheny1piperazino 1 oxopropyl1-pyrazole.

9. The compound of claim 1 which is:

1-(2-primidinyl)-5-methyl-4-[3-(4-o-methoxyphenylpiperazino 1 -oxopropyl -pyrazole.

10. The compound of claim 1 which is:

1-(4-pyrimidinyl)-5-methyl-4-[3-(4-phenylpiperazino l -oxopropyl l-pyrazole.

l 1. The compound of claim 1 which is:

l-(4-pyrimidinyl )-5 -methyl-4-[ 3-( 4-o-tolypiperazino )-1-oxopropyl]-pyrazole.

12. The compound of claim 1 which is:

1-( 4-pyrimidinyl )-5-methyl-4- 3-( 4-p-chlorophenylpiperazino 1 -oxopropyl -pyrazole.

13. The compound of claim 1 which is:

1-( 4-methoxy-2-pyrimidinyl )-5-methy1-4- phenylpiperazino)-1-oxopropyl]-pyrazole.

14. The compound of claim 1 which is:

l-( 6-methoxy-4-pyrimidinyl )-5-methyl-4- 3 4- pheny1piperazino)-1-oxopropyl]-pyrazole.

15. The compound of claim 1 which is:

1-(4,6-dimethyl-2-pyrimidinyl )-4-[ 3-( 4-phenyl- 1 ,2,5 ,6-tetrahydro- 1 -pyridyl l -oxopropyl 5methylpyrazole.

16. The compound of claim 1 which is:

1-( Z-pyrimidinyl )-3 ,5-dimethyl-4-[ 3-( 4-o-tolylpiperazino)- l-oxopropyl1-pyrazole.

17. The compound of claim 1 which is:

1-(2-pyrimidinyl )-5-methyl-4-[3-(4-phenyll piperidyl)-1-oxopropyl]-pyrazole.

'18. The compound of claim 1 which is:

l-(2-pyrimidiny1)-5-methyl-4-[3-( 4-p-chloropheny1- 4-hydroxy-1-piperidyl)- l-oxopropyll-pyrazole.

19. The compound of claim 1 which is:

1-( Z-pyrimidinyl )-5-methyl-4-[ 3-( 4-p-fluorophenyll ,2,5,6-tetrahydro-l-pyridyl)-1-oxopropyl]- pyrazole.

20. The compound of claim I which is:

l-(2-pyrimidinyl)-5-methyl-4-[3-(4-phenyl-1,2,5 ,6-

tetrahydro- 1-pyridyl)- 1-oxopropyl1-pyrazole.

21. The compound of claim 1 which is:

l-( Z-pyrimidinyl)-5-methyl-4-[3-(4-p-chlorophenylhaving one to five carbon atoms, and a halogen atom.

l ,2,5 ,6-tetrahydropyridyl)-l-oxopropyl1-pyraz0le. 25. The compound of claim 24 which is: 22. The compound of claim 1 which is: l-( Z-pyrimidinyl)-4-acetyl-5-methyl-pyrazole. y -py y y 26. The compound of claim 24 which is:

phenyl-l r y 1-pyri y1)- 1 1-( 4-methoxy-2-pyrimidinyl )-4-acetyl-5 -methylopropyll-pyrazole. pyrazole. 23. The compound of claim 1 which is: 27 The compound f l i 24 hi h i 1 4-methoxy-6-methyl-2-pyrimidinyl )-5 -methyl-4- 3-(4-o-tolylpiperazino l -oxopropyl]-pyrazole. 24. A compound represented by the formula:

1-( 4,6-dimethyl-2-pyrimidinyl )-4-acetyl-5-methylpyrazole.

28. The compound of claim 24 which is:

l-(4-methoxy-6-methyl-2-pyrimidinyl)-4-acetyl-5- rtiethyl-pyrazole.

R COC'HB 29. The compound of claim 24 which is:

I-(4-methoxy-5-bromo-6-methyl-2-pyrimidinyl)-4- R acetyl-S -methyl-pyrazole.

f 30. The compound of claim 24 which is:

PY l-(4,6-dimethoxy-2-pyrimidinyl)-4-acetyl-5-methylpyrazole. 31. The compound of claim 24 which is:

1-(4- rimidin l)-4-acet I-S-meth lrazole wherein R and R each represent a hydrogen atom or 32 g y d f l 24 an alkyl group having one to five carbon atoms and Py e sg r 9 h 1 represents a pyrimidinyl group having one or more sub- 'pymm my 'acety y stituents selected from the group consisting of an alkyl pyrazole group having one to five carbon atoms, an alkoxy group 25 

2. The compound of claim 1 which is: 1-(2-pyrimidinyl)-5-methyl-4-(3-(4-phenylpiperazino)-1-oxopropyl)- pyrazole.
 3. The compound of claim 1 which is: 1-(2-pyrimidinyl)-5-methyl-4-(3-(4-o-tolylpiperazino)-1-oxopropyl)-pyrazole.
 4. The compound of claim 1 which is: 1-(2-pyrimidinyl)-5-methyl-4-(3-(4-p-tolylpiperazino)-1-oxopropyl)-pyrazole.
 5. The compound of claim 1 which is: 1-(2-pyrimidinyl)-5-methyl-4-(3-(4-o-chlorophenylpiperazino)-1-oxopropyl) -pyrazole.
 6. The compound of claim 1 which is: 1-(2-pyrimidinyl)-5-methyl-4-(3-(4-m-chlorophenylpiperazino)-1-oxopropyl) -pyrazole.
 7. The compound of claim 1 which is: 1-(2-pyrimidinyl)-5-methyl-4-(3-(4-p-chlorophenlpiperazino)-1-oxopropyl) -pyrazole.
 8. The compound of claim 1 which is: 1-(2-pyrimidinyl)-5-methyl-4-(3-(4-p-fluorophenylpiperazino)-1-oxopropyl) -pyrazole.
 9. The compound of claim 1 which is: 1-(2-primidinyl)-5-methyl-4-(3-(4-o-methoxyphenylpiperazino)-1-oxopropyl) -pyrazole.
 10. The compound of claim 1 which is: 1-(4-pyrimidinyl)-5-methyl-4-(3-(4-phenylpiperazino)-1-oxopropyl)-pyrazole.
 11. The compound of claim 1 which is: 1-(4-pyrimidinyl)-5-methyl-4-(3-(4-o-tolypiperazino )-1-oxopropyl)-pyrazole.
 12. The compound of claim 1 which is: 1-(4-pyrimidinyl)-5-methyl-4-(3-(4-p-chlorophenylpiperazino)-1-oxopropyl) -pyrazole.
 13. The compound of Claim 1 which is: 1-(4-methoxy-2-pyrimidinyl)-5-methyl-4- (3-(4-phenylpiperazino)-1-oxopropyl)-pyrazole.
 14. The compound of claim 1 which is: 1-(6-methoxy-4-pyrimidinyl)-5-methyl-4-(3-(4-phenylpiperazino)-1-oxopropyl) -pyrazole.
 15. The compound of claim 1 which is: 1-(4,6-dimethyl-2-pyrimidinyl)-4-(3-(4-phenyl-1,2,5,6-tetrahydro-1-pyridyl) -1-oxopropyl)-5methylpyrazole.
 16. The compound of claim 1 which is: 1-(2-pyrimidinyl)-3,5-dimethyl-4-(3-(4-o-tolylpiperazino)-1-oxopropyl) -pyrazole.
 17. The compound of claim 1 which is: 1-(2-pyrimidinyl)-5-methyl-4-(3-(4-phenyl-1-piperidyl)-1-oxopropyl) -pyrazole.
 18. The compound of claim 1 which is: 1-(2-pyrimidinyl)-5-methyl-4-(3-(4-p-chlorophenyl-4-hydroxy-1-piperidyl)-1 -oxopropyl)-pyrazole.
 19. The compound of claim 1 which is: 1-(2-pyrimidinyl)-5-methyl-4-(3-(4-p-fluorophenyl-1,2,5,6-tetrahydro-1 -pyridyl)-1-oxopropyl)-pyrazole.
 20. The compound of claim 1 which is: 1-(2-pyrimidinyl)-5-methyl-4-(3-(4-phenyl-1,2,5,6-tetrahydro-1-pyridyl)-1 -oxopropyl)-pyrazole.
 21. The compound of claim 1 which is: 1-(2-pyrimidinyl)-5-methyl-4-(3-(4-p-chlorophenyl-1,2,5,6-tetrahydropyridyl)-1-oxopropyl)-pyrazole.
 22. The compound of claim 1 which is: 1-(4,6-dimethyl-2-pyrimidinyl)-5-methyl-4-(3-(4-phenyl-1,2,5,6-tetrahydro-1 -pyridyl)-1-oxopropyl)-pyrazole.
 23. The compound of claim 1 which is: 1-(4-methoxy-6-methyl-2-pyrimidinyl)-5-methyl-4-(3-(4-o-tolylpiperazino)-1 -oxopropyl)-pyrazole.
 24. A compound represented by the formula:
 25. The compound of claim 24 which is: 1-(2-pyrimidinyl)-4-acetyl-5-methyl-pyrazole.
 26. The compound of claim 24 which is: 1-(4-methoxy-2-pyrimidinyl)-4-acetyl-5-methyl-pyrazole.
 27. The compound of claim 24 which is: 1-(4,6-dimethyl-2-pyrimidinyl)-4-acetyl-5-methyl-pyrazole.
 28. The compound of claim 24 which is: 1-(4-methoxy-6-methyl-2-pyrimidinyl)-4-acetyl-5-methyl-pyrazole.
 29. The compound of claim 24 which is: 1-(4-methoxy-5-bromo-6-methyl-2-pyrimidinyl)-4-acetyl-5-methyl-pyrazole.
 30. The compound of claim 24 which is: 1-(4,6-dimethoxy-2-pyrimidinyl)-4-acetyl-5-methyl-pyrazole.
 31. The compound of claim 24 which is: 1-(4-pyrimidinyl)-4-acetyl-5-methyl-pyrazole.
 32. The compound of claim 24 which is: 1-(6-methoxy-4-pyrimidinyl)-4-acetyl-5-methyl-pyrazole. 